A Further Step Toward Safe and Effective Myocardial Regeneration by Cardiac Progenitors Derived From Embryonic Stem Cells
نویسندگان
چکیده
Alain Bel, MD; Valérie Planat-Bernard, PhD, MD; Atsuhiro Saito, PhD; Lionel Bonnevie, MD; Valérie Bellamy, MSc; Laurent Sabbah, MD; Linda Bellabas; Benjamin Brinon, MSc; Valérie Vanneaux, MD, PhD; Pascal Pradeau, DVet; Séverine Peyrard, MSc; Jérôme Larghero, MD, PhD; Julia Pouly, MD; Patrice Binder, MD; Sylvie Garcia, PhD; Tatsuya Shimizu, PhD; Yoshiki Sawa, MD; Teruo Okano, PhD; Patrick Bruneval, MD; Michel Desnos, MD, PhD; Albert A. Hagège, MD, PhD; Louis Casteilla, PhD; Michel Pucéat, PhD; Philippe Menasché, MD, PhD
منابع مشابه
Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells.
BACKGROUND The safety and efficacy of myocardial regeneration using embryonic stem cells are limited by the risk of teratoma and the high rate of cell death. METHODS AND RESULTS To address these issues, we developed a composite construct made of a sheet of adipose tissue-derived stroma cells and embryonic stem cell-derived cardiac progenitors. Ten Rhesus monkeys underwent a transient coronary...
متن کاملAre Stem Cells the next Therapeutic Tool for Heart Repair?
Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and Europe. In recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. A stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...
متن کاملP-74: Effect of Fndc5 Overexpression onCardiac Differentiation Rate of mESCs
Background: Fibronectin type III domain-containing 5 proteins (Fndc5), an exercise hormone, formerly known as peroxisomal protein that was cloned in 2002. Transcript profile analysis of Fndc5 revealed high degree of expression in heart, skeletal muscle and brain. Our recent studies indicated a significant increase (approximately 10 folds) in mRNA level of Fndc5 when mouse embryonic stem cells w...
متن کاملThe Effect of Cardio Gel and Matrigel on the Ultrastructure of Cardiomyocytes Derived From Mouse Embryonic Stem Cells
Purpose: To investigate the effect of cardiogel and matrigel on the ultrastructure of embryonic stem cell-derived cardiomyocytes. ECM: Extracellular Matrix derived from cardiac fibroblasts (cardiogel), commercial extracellular matrix (matrigel) and control group (without ECM) were cultured for up to 21 days. Ultrastructural properties of cardiomyocytes were evaluated by transmitting electron mi...
متن کاملPancreatic Differentiation of Sox 17 Knock-in Mouse Embryonic Stem Cells in Vitro
The way to overcome current limitations in the generation of glucose-responsive insulin-producing cells is selective enrichment of the number of definitive endoderm (DE) progenitor cells. Sox17 is the marker of mesendoderm and definitive endoderm. The aim of the present research was to study the potential of Sox17 knock-in CGR8 mouse embryonic stem (ES) cells to differentiate into insulin produ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010